HIGH ACCUMULATION OF MINOR COMPONENTS OF HEMATOPORPHYRIN DERIVATIVE (HpD) IN VITRO
نویسندگان
چکیده
منابع مشابه
Laser-induced Fluorescence Studies of Hematoporphyrin Derivative (hpd) In Normal and Tumor-tissue of Rat
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Nature of the tumor-localizing components of hematoporphyrin derivative.
Hematoporphyrin derivative linked by ether bonds (HE) was synthesized by unambiguous procedures in order to compare its properties to hematoporphyrin derivative (HpD). Reverse phase high performance liquid and gel filtration chromatography were used to compare the HE derivatives to HpD. The cellular uptake of HE derivatives was compared to HpD using the WEHI 3B (D+) cell line and was shown to b...
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Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This appare...
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ژورنال
عنوان ژورنال: THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE
سال: 1990
ISSN: 0288-6200
DOI: 10.2530/jslsm1980.11.supplement_231